Collagenolytic metalloenzymes of the human neutrophil
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چکیده
منابع مشابه
Collagenolytic metalloenzymes of the human neutrophil. Characteristics, regulation and potential function in vivo.
The primary role of the human neutrophil is to destroy pathogenic microbes that have invaded the host [I, 2]t. Neutrophils accomplish this task by using their plasma membrane to engulf and sequester the microorganisms into the formed intracellular compartment which is termed the phagocytic vacuole. Simultaneous with the initiation of vacuole formation, a portion of the lysosomal granules of the...
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A collagenolytic enzyme was extracted from the 6000 g sediment of homogenized postmortal human colon tissue. The enzyme digests native collagen at neutral pH. The enzyme has been concentrated by ammonium sulfate precipitation. The collagenolytic activity was measured using [1-14C]acetylated calf skin collagen, solubilized in 0.1 g/1 acetic acid. There was a significant inactivation of the enzym...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 1986
ISSN: 0006-2952
DOI: 10.1016/0006-2952(86)90412-0